Acne or acne vulgaris is a chronic dermatological disease which primarily affects the face, but can also impact other parts of the body. Acne is caused by abnormal desquamation, leading to the clogging of pilosebaceous units (hair follicle and sebaceous glands) and eventual inflammation of the skin due to bacterial growth.
In medical setting, acne is typically treated with topical salicylic acid, retinoic acid, or a combination of both. With the overall goal of normalising skin desquamation, salicylic acid acts as an exfoliant to promote removal of dead skin cells, while retinoic acid regulates the growth of keratinocytes and suppresses several inflammatory pathways linked to acne. However, therapeutic uses of retinoic acid have been associated with undesirable effects such as skin irritation and dryness. Fortunately, recent research has discovered a natural plant-derived compound called Bakuchiol, which mimics the efficacy of retinoic acid but is non-irritating. A clinical study in 2011 found that the combination of salicylic acid and retinoic acid resulted in the reduction of acne lesions and inflammation up to 70% compared to control. Interestingly, the combination of both ingredients also resulted in synergistic inhibition of bacterial growth, which was not observed when either ingredient was used alone.
The latest innovation by smith-meyerlab, known as PURI-5 Power Activ Concentrate, marries both Bakuchiol and Salicylic Acid to combat acne. The product is intended for use in mild to moderate acne patients, and suitable for all ages and skin conditions including sensitive skin. According to Dr. Kenneth Chew, Head of DMS Innovation Excellence Centre (IEC), the inclusion of encapsulated salicylic acid in PURI-5 Power Activ Concentrate reduces the stinging effects commonly associated with non-encapsulated form, while providing longer lasting efficacies. Moreover, the product is included with Boswellia Serrata Extract to reduce the potential stinging effects of salicylic acid, as well as enhance the healing process of acne. PURI-5 Power Activ Concentrate is recommended for use twice daily, after cleansing. It is now available in selective Family Medicine Specialist Clinics, Dermatologists and Aesthetic Clinics throughout Malaysia.
Source:
Chaudhuri, R.K. and Marchio, F. 2011. Bakuchiol In The Management of Acne-Affected Skin. Cosmetics & Toiletries Magazine, Vol. 126; No.7.